Effects of Shikunshito-Kamiho on Fecal Enzymes and Formation of Aberrant Crypt Foci Induced by 1,2-Dimethylhydrazine.

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  • YOO Bong-Ha
    Department of Internal Medicine, Oriental Medical College, Kyunghee University
  • LEE Beom-Han
    Department of Internal Medicine, Oriental Medical College, Kyunghee University
  • KIM Jin-Sung
    Department of Internal Medicine, Oriental Medical College, Kyunghee University
  • KIM Nam-Jae
    Department of Oriental Pharmacy, Oriental Medical Hospital, Kyunghee University
  • KIM Sung-Hoon
    Department of Oncology, Graduate School of East-West Medical Science
  • RYU Ki-Won
    Department of Oncology, Graduate School of East-West Medical Science

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Shikunshito-Kamiho (SKTK) is a traditional Chinese medicine composed of eight crude drugs (Ginseng Radix, Hoelen, Atractylodis Rhizoma, Glycyrrhizae Radix, Prunellae Spica, Ostreae Testa, Laminaria Thallus, Sargassum). We investigated the effects of SKTK on pH, ammonia, fecal enzymes such as β-glucuronidase, tryptophanase, urease, and formation aberrant crypt foci in the colon carcinogenesis model induced by 1, 2-dimethylhydrazine (DMH). Water extract of SKTK was administered orally for 5 weeks to DMH-treated mice as 0.5% and 1.5% of the diet. β-Glucuronidase, pH and tryptophanase were significantly inhibited after treatment of 0.5% and 1.5% SKTK, while urease was significantly reduced only during and after treatment of 1.5% SKTK as compared with control data. However, the ammonia concentration wasn’t different in SKTK treated groups from control group. The incidence number of aberrant crypts foci (ACF) and aberrant crypts/focus in colon was significantly decreased by 0.5% and 1.5% SKTK mixed diets compared with that in rats treated with DMH alone. These results suggest that SKTK exterts anticarcinogenic activity on experimental murine colorectal cancer.

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