Genetic association of the functional <i>CDHR3</i> genotype with early-onset adult asthma in Japanese populations
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- Kanazawa Jun
- Department of Pulmonary Medicine, University of Tsukuba
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- Masuko Hironori
- Department of Pulmonary Medicine, University of Tsukuba
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- Yatagai Yohei
- Department of Pulmonary Medicine, University of Tsukuba
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- Sakamoto Tohru
- Department of Pulmonary Medicine, University of Tsukuba
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- Yamada Hideyasu
- Department of Pulmonary Medicine, University of Tsukuba
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- Kaneko Yoshiko
- Department of Pulmonary Medicine, University of Tsukuba
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- Kitazawa Haruna
- Department of Pulmonary Medicine, University of Tsukuba
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- Iijima Hiroaki
- Tsukuba Medical Center
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- Naito Takashi
- Tsukuba Medical Center
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- Saito Takefumi
- National Hospital Organization, Ibarakihigashi National Hospital
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- Noguchi Emiko
- Department of Medical Genetics, University of Tsukuba
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- Konno Satoshi
- First Department of Medicine, Hokkaido University School of Medicine
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- Nishimura Masaharu
- First Department of Medicine, Hokkaido University School of Medicine
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- Hirota Tomomitsu
- Laboratory for Respiratory and Allergic Diseases, Center for Integrative Medical Sciences, Institute of Physical and Chemical Research (RIKEN)
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- Tamari Mayumi
- Laboratory for Respiratory and Allergic Diseases, Center for Integrative Medical Sciences, Institute of Physical and Chemical Research (RIKEN)
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- Hizawa Nobuyuki
- Department of Pulmonary Medicine, University of Tsukuba
Bibliographic Information
- Other Title
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- Genetic association of the functional CDHR3 genotype with early-onset adult asthma in Japanese populations
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Abstract
<p>Background: Recent studies have demonstrated that a coding SNP (rs6967330, Cys529→Tyr) in cadherin-related family member 3 (CDHR3), which was previously associated with wheezing illness and hospitalizations in infancy, could support efficient human rhinovirus C (RV-C) entry and replication. Here, we sought to examine the genetic contribution of this variant to the development of adult asthma.</p><p>Methods: We performed a candidate gene case–control association study of 2 independent Japanese populations (a total of 3366 adults). The odds ratios (ORs) for association of the A allele at rs6967330 with adult asthma were calculated according to age at onset of asthma. In addition, the effect of the CDHR3 genotype on the development of specific asthma phenotypes was examined.</p><p>Results: The A allele was associated with asthma (OR = 1.56; Mantel–Haenszel p = 0.0040) when the analysis was limited to patients with early-onset adult asthma. In addition, when the analysis was limited to atopic individuals, a stronger association of the CDHR3 variant with early-onset asthma was found, and interaction of the CDHR3 genotype with atopy was demonstrated. Finally, a significant association of this variant was specifically found with a phenotype of asthma characterized by atopy, early-onset, and lower lung function.</p><p>Conclusions: Our study supports the concept that the CDHR3 variant is an important susceptibility factor for severe adult asthma in individuals who develop the disease in early life. The interaction between the CDHR3 variant and atopy indicates that genetic predisposition to early respiratory viral infection is combined with atopy in promoting asthma.</p>
Journal
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- Allergology International
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Allergology International 66 (4), 563-567, 2017
Japanese Society of Allergology
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Details
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- CRID
- 1390001204631138816
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- NII Article ID
- 130006179446
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- NII Book ID
- AA11091750
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- ISSN
- 14401592
- 13238930
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- HANDLE
- 2241/00159690
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- Text Lang
- en
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- Data Source
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- JaLC
- IRDB
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed