Role of 5-Hydroxytryptamine2C Receptors in Marble-Burying Behavior in Mice
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- Egashira Nobuaki
- Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University Department of Pharmacy, Kyushu University Hospital
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- Okuno Ryoko
- Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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- Shirakawa Atsunori
- Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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- Nagao Masaki
- Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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- Mishima Kenichi
- Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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- Iwasaki Katsunori
- Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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- Oishi Ryozo
- Department of Pharmacy, Kyushu University Hospital
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- Fujiwara Michihiro
- Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
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Abstract
We examined the role of 5-hydroxytryptamine2C (5-HT2C) receptors in marble-burying behavior in mice. When administered alone, the selective 5-HT2C agonist WAY161503 (3 mg/kg) inhibited marble-burying behavior. Moreover, the selective 5-HT2C antagonist SB242084 (3 mg/kg) reversed the inhibition of marble-burying behavior by 2,5-dimethoxy-4-iodoamphetamine (DOI) (1 mg/kg) or WAY161503 (3 mg/kg). Similarly, SB242084 (1 mg/kg) reversed the inhibition of marble-burying behavior by fluvoxamine (30 mg/kg) or paroxetine (3 mg/kg). These results suggest that 5-HT2C receptors play a role in marble-burying behavior in mice.
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 35 (3), 376-379, 2012
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390001204631171200
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- NII Article ID
- 130001872319
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- NII Book ID
- AA10885497
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- COI
- 1:STN:280:DC%2BC383nvVWgsQ%3D%3D
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- ISSN
- 13475215
- 09186158
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- NDL BIB ID
- 023439849
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- PubMed
- 22382324
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed