Metabolic Changes in Paraquat Poisoned Patients and Support Vector Machine Model of Discrimination
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- Wang Xianqin
- Analytical and Testing Center, Wenzhou Medical University
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- Zhang Meiling
- Analytical and Testing Center, Wenzhou Medical University
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- Ma Jianshe
- Analytical and Testing Center, Wenzhou Medical University
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- Zhang Yuan
- Analytical and Testing Center, Wenzhou Medical University
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- Hong Guangliang
- Department of emergency, The First Affiliated Hospital of Wenzhou Medical University
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- Sun Fa
- Analytical and Testing Center, Wenzhou Medical University
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- Lin Guanyang
- Department of Pharmacy, The First Affliated Hospital of Wenzhou Medical University
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- Hu Lufeng
- Department of Pharmacy, The First Affliated Hospital of Wenzhou Medical University
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抄録
Numerous people die of paraquat (PQ) poisoning every year in the world. Although several studies regarding paraquat (PQ) poisoning have been conducted, the metabolic changes in plasma remain unknown. In this study, the metabolomics of 15 PQ poisoned patients with plasma PQ concentrations in excess of 0.1 µg/mL and 16 healthy volunteers were investigated. The plasma samples were evaluated through the use of gas chromatography-mass spectrometry (GC/MS) and analyzed by partial least-squares discriminant analysis (PLS-DA). Based on the metabolomics data, a support vector machine (SVM) discrimination model was developed. The results showed the plasma levels of urea, glucose oxime and L-phenylalanine decreased and cholesterol increased in PQ poisoned patients in comparison to healthy volunteers. The SVM discrimination model was developed, and performed with a high degree of accuracy, to distinguish PQ poisoned patients from healthy volunteers. In conclusion, metabolic pathways including the urea cycle, and amino acid, glucose, and cholesterol metabolism were impaired after PQ poisoning. An SVM discrimination model, based on metabolomics data, was established and may become a new powerful tool for the diagnosis of PQ poisoning.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 38 (3), 470-475, 2015
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204631331328
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- NII論文ID
- 130004872277
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 026193342
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- PubMed
- 25757930
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可