Effects of the Nonsteroidal Anti-inflammatory Drug Celecoxib on Mitochondrial Function
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- Tatematsu Yohei
- Graduate School of Pharmaceutical Sciences, Suzuka University of Medical Science
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- Fujita Haruhi
- Graduate School of Pharmaceutical Sciences, Suzuka University of Medical Science
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- Hayashi Hiroki
- Graduate School of Pharmaceutical Sciences, Suzuka University of Medical Science
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- Yamamoto Atsushi
- Graduate School of Pharmaceutical Sciences, Suzuka University of Medical Science
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- Tabata Atsushi
- Department of Bioengineering, Division of Bioscience and Bioindustry, Graduate School of Technology, Industrial and Social Sciences, Tokushima University
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- Nagamune Hideaki
- Department of Bioengineering, Division of Bioscience and Bioindustry, Graduate School of Technology, Industrial and Social Sciences, Tokushima University
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- Ohkura Kazuto
- Graduate School of Pharmaceutical Sciences, Suzuka University of Medical Science
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<p>Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used to treat inflammation and pain. In the present study, we examined the effects of celecoxib, a cyclooxygenase-2 (COX-2)-selective NSAID, on rat liver mitochondrial function. Celecoxib dose-dependently induced mitochondria swelling, which was not suppressed by cyclosporine A (CsA). The oxygen consumption rate in mitochondria-suspended solution was facilitated by the addition of celecoxib, and its uncoupling activity was observed. Celecoxib also suppressed SF6847-induced uncoupling, and appeared to exert inhibitory effects on the electron transport chain. Celecoxib suppressed the state 3 oxygen consumption rate in the presence of ADP. Protein release from the mitochondrial matrix was detected following the addition of celecoxib, and aldehyde dehydrogenase 2 (ALDH2) and hydroxymethylglutaryl-CoA (HMG-CoA) synthase 2 (HMGCS2) bands were confirmed in a Western blot analysis. On the other hand, protein release of cytochrome C (CytC), which is an inducer of apoptosis, from the intermembrane space was not observed. Celecoxib enhanced the membrane permeability of human erythrocytes and synthesized liposomes dose-dependently. It then induced the membrane-involving mitochondrial swelling and suppressed mitochondrial function.</p>
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 41 (3), 319-325, 2018
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204631634304
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- NII論文ID
- 130006407351
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 028854160
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- PubMed
- 29491208
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可