β-Amyloid42 Induces Desensitization of CXC Chemokine Receptor-4 via Formyl Peptide Receptor in Neural Stem/Progenitor Cells
-
- Zhang Can
- School of Pharmacy, Shanghai Jiaotong University
-
- Wang Ze-Jian
- School of Pharmacy, Shanghai Jiaotong University
-
- Lok Keng-Hoe
- School of Pharmacy, Shanghai Jiaotong University
-
- Yin Ming
- School of Pharmacy, Shanghai Jiaotong University
書誌事項
- タイトル別名
-
- β-Amyloid<sub>42</sub> Induces Desensitization of CXC Chemokine Receptor-4 <i>via</i> Formyl Peptide Receptor in Neural Stem/Progenitor Cells
この論文をさがす
説明
The deposition of β-amyloid (Aβ) plaques and progressive loss of neurons are two main characteristics of Alzheimer’s disease (AD). Supplement of neural stem/progenitor cells (NSPCs) is a promising strategy for repair of the neurodegenerative diseases. However, hostile microenvironment of neurodegenerative brain is harmful for the neuroregeneration. Aβ42 promoted the proliferation of NSPCs. Moreover, Aβ42 (10—1000 nM) promoted the migration of NSPCs in a dose-dependent manner. The attraction of NSPCs toward Aβ42 was significantly offset by 10 μM cyclosporin H, a potent and selective formyl peptide receptor antagonist. After incubation with Aβ42 for 9 d, the migration ability of NSPCs was significantly decreased (p<0.05). The expression of formyl peptide receptor (FPR) and CXC chemokine receptor-4 (CXCR4) were significantly decreased in NSPCs. The expression of G protein-coupled receptor kinase 2 (GRK2) was up-regulated on the membrane of NSPCs correspondingly. Our results suggested that Aβ42 decreases the migratory capacity of NSPCs by FPR heterologous desensitization after long time incubation, and GRK2 in NSPCs may be responsible for the damaged migratory capacity.
収録刊行物
-
- Biological & Pharmaceutical Bulletin
-
Biological & Pharmaceutical Bulletin 35 (2), 131-138, 2012
公益社団法人 日本薬学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390001204631881600
-
- NII論文ID
- 130001872285
-
- NII書誌ID
- AA10885497
-
- ISSN
- 13475215
- 09186158
-
- NDL書誌ID
- 023408339
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可