β-Amyloid<sub>42</sub> Induces Desensitization of CXC Chemokine Receptor-4 <i>via</i> Formyl Peptide Receptor in Neural Stem/Progenitor Cells
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- Zhang Can
- School of Pharmacy, Shanghai Jiaotong University
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- Wang Ze-Jian
- School of Pharmacy, Shanghai Jiaotong University
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- Lok Keng-Hoe
- School of Pharmacy, Shanghai Jiaotong University
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- Yin Ming
- School of Pharmacy, Shanghai Jiaotong University
Bibliographic Information
- Other Title
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- β-Amyloid42 Induces Desensitization of CXC Chemokine Receptor-4 via Formyl Peptide Receptor in Neural Stem/Progenitor Cells
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Abstract
The deposition of β-amyloid (Aβ) plaques and progressive loss of neurons are two main characteristics of Alzheimer’s disease (AD). Supplement of neural stem/progenitor cells (NSPCs) is a promising strategy for repair of the neurodegenerative diseases. However, hostile microenvironment of neurodegenerative brain is harmful for the neuroregeneration. Aβ42 promoted the proliferation of NSPCs. Moreover, Aβ42 (10—1000 nM) promoted the migration of NSPCs in a dose-dependent manner. The attraction of NSPCs toward Aβ42 was significantly offset by 10 μM cyclosporin H, a potent and selective formyl peptide receptor antagonist. After incubation with Aβ42 for 9 d, the migration ability of NSPCs was significantly decreased (p<0.05). The expression of formyl peptide receptor (FPR) and CXC chemokine receptor-4 (CXCR4) were significantly decreased in NSPCs. The expression of G protein-coupled receptor kinase 2 (GRK2) was up-regulated on the membrane of NSPCs correspondingly. Our results suggested that Aβ42 decreases the migratory capacity of NSPCs by FPR heterologous desensitization after long time incubation, and GRK2 in NSPCs may be responsible for the damaged migratory capacity.
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 35 (2), 131-138, 2012
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390001204631881600
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- NII Article ID
- 130001872285
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- NII Book ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL BIB ID
- 023408339
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed