Application of Curcumin to Heart Failure Therapy by Targeting Transcriptional Pathway in Cardiomyocytes
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- Sunagawa Yoichi
- Human Health Sciences, Graduate School of Medicine, Kyoto University Division of Translational Research, Clinical Research Institute, Kyoto Medical Center, National Hospital Organization Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka
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- Wada Hiromichi
- Division of Translational Research, Clinical Research Institute, Kyoto Medical Center, National Hospital Organization
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- Suzuki Hidetoshi
- Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka
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- Sasaki Hiroki
- Theravalues Corporation
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- Imaizumi Atsushi
- Theravalues Corporation
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- Fukuda Hiroyuki
- Theravalues Corporation
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- Hashimoto Tadashi
- Theravalues Corporation
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- Katanasaka Yasufumi
- Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka
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- Shimatsu Akira
- Clinical Research Institute, Kyoto Medical Center, National Hospital Organization
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- Kimura Takeshi
- Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
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- Kakeya Hideaki
- Department of System Chemotherapy and Molecular Sciences, Division of Bioinformatics and Chemical Genomics, Graduate School of Pharmaceutical Sciences, Kyoto University
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- Fujita Masatoshi
- Human Health Sciences, Graduate School of Medicine, Kyoto University
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- Hasegawa Koji
- Division of Translational Research, Clinical Research Institute, Kyoto Medical Center, National Hospital Organization
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- Morimoto Tatsuya
- Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka
書誌事項
- タイトル別名
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- A Novel Drug Delivery System of Oral Curcumin Markedly Improves Efficacy of Treatment for Heart Failure after Myocardial Infarction in Rats
- A novel drug delivery system of oral curcumin markedly improves efcacy of treatment for heart failure afer myocardial infarction in rats
この論文をさがす
説明
Curcumin is an inhibitor of p300 histone acetyltransferase activity, which is associated with the deterioration of heart failure. We reported that native curcumin, at a dosage of 50 mg/kg, prevented deterioration of the systolic function in rat models of heart failure. To achieve more efficient oral pharmacological therapy against heart failure by curcumin, we have developed a novel drug delivery system (DDS) which markedly increases plasma curcumin levels. At the dosage of 0.5 mg/kg, DDS curcumin but not native curcumin restored left ventricular fractional shortening in post-myocardial infarction rats. Thus, our DDS strategy will be applicable to the clinical setting in humans.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 35 (2), 139-144, 2012
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204631883520
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- NII論文ID
- 130001872286
- 130003361361
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- NII書誌ID
- AA10885497
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- COI
- 1:STN:280:DC%2BC387pt1yntA%3D%3D
- 1:STN:280:DC%2BC3s3otFaitg%3D%3D
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- ISSN
- 13475215
- 09186158
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- Web Site
- http://id.ndl.go.jp/bib/023408351
- https://ndlsearch.ndl.go.jp/books/R000000004-I023408351
- http://id.ndl.go.jp/bib/024173317
- https://ndlsearch.ndl.go.jp/books/R000000004-I024173317
- http://www.jstage.jst.go.jp/article/bpb/35/2/35_2_139/_pdf
- https://www.jstage.jst.go.jp/article/bpb/36/1/36_b212022/_pdf
- https://search.jamas.or.jp/link/ui/2012244716
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可