Anti-allergic Effect of Bee Venom in an Allergic Rhinitis Mouse Model
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- Shin Seung-Heon
- Department of Otolaryngology-Head and Neck Surgery, Catholic University of Daegu
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- Kim Yee-Hyuk
- Department of Otolaryngology-Head and Neck Surgery, Catholic University of Daegu
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- Kim Jeong-Kyu
- Department of Otolaryngology-Head and Neck Surgery, Catholic University of Daegu
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- Park Kwan-Kyu
- Department of Pathology, School of Medicine, Catholic University of Daegu
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Description
Bee venom (BV) has been used as an anti-inflammatory and immune modulating agent in Oriental medicine. This study used a mouse model to investigate the anti-allergic effect of BV, which is used in the treatment of various inflammatory diseases in traditional medicine. BV was obtained from the National Institute of Agricultural Science and Technology of Korea. Female BALB/C mice were sensitized by intraperitoneal injection of ovalbumin (OVA). BV was administered nasally prior to the intranasal instillation of OVA. Allergic behavior, serum OVA-specific immunoglobulin E (IgE), interleukin (IL)-4, IL-10, and interferon-gamma (INF-γ) levels in nasal lavage fluid were measured. Hematoxylin–eosin and periodic acid-Schiff staining were performed to evaluate histological change. BV attenuated nasal symptoms and inhibited the production of OVA-specific IgE and IL-4 in sensitized mice. The degree of inflammatory cell infiltration and goblet cell hyperplasia was attenuated by BV. Thus, BV effectively reduced allergic inflammation in a mouse model of allergic rhinitis, suggesting its potential as a useful therapeutic agent to treat allergic rhinitis.
Journal
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- Biological and Pharmaceutical Bulletin
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Biological and Pharmaceutical Bulletin 37 (8), 1295-1300, 2014
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390001204632213760
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- NII Article ID
- 130004677535
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- NII Book ID
- AA10885497
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- COI
- 1:STN:280:DC%2BC2cbos1Kisw%3D%3D
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- ISSN
- 13475215
- 09186158
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- NDL BIB ID
- 025609868
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- PubMed
- 25087951
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed