Potent Anti-inflammatory and Analgesic Actions of the Chloroform Extract of Dendropanax morbifera Mediated by the Nrf2/HO-1 Pathway
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- Akram Muhammad
- College of Pharmacy Institute of Pharmaceutical Science and Technology, Hanyang University
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- Kim Kyeong-A
- College of Pharmacy Institute of Pharmaceutical Science and Technology, Hanyang University
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- Kim Eun-Sun
- College of Pharmacy Institute of Pharmaceutical Science and Technology, Hanyang University
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- Syed Ahmed Shah
- College of Pharmacy Institute of Pharmaceutical Science and Technology, Hanyang University
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- Kim Chul Young
- College of Pharmacy Institute of Pharmaceutical Science and Technology, Hanyang University
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- Lee Jong Soo
- CL Institute Korea (CLIK) Department of Chemistry, Ajou University
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- Bae Ok-Nam
- College of Pharmacy Institute of Pharmaceutical Science and Technology, Hanyang University
書誌事項
- タイトル別名
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- Potent Anti-inflammatory and Analgesic Actions of the Chloroform Extract of <i>Dendropanax morbifera</i> Mediated by the Nrf2/HO-1 Pathway
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説明
Dendropanax morbifera LEVEILLE (DP) has been used in traditional Korean medicines to treat a variety of inflammatory diseases. Although the in vitro anti-inflammatory potential of this plant is understood, its in vivo efficacy and underlying molecular mechanism of anti-inflammatory effects are largely unknown. We elucidated the anti-inflammatory and analgesic activities and the underlying molecular mechanisms of DP using in vitro and in vivo models. Lipopolysaccharide (LPS)-stimulated murine macrophages were used to analyze the in vitro anti-inflammatory potential of DP extract and to elucidate the underlying mechanisms. In vivo animal models of phorbol 12-myristate 13-acetate (TPA)-induced ear edema and acetic acid-induced writhing response tests were used to analyze the in vivo anti-inflammatory effects and anti-nociceptive effects of DP extract, respectively. Methanolic extract of DP (DPME) significantly inhibited the release of nitric oxide (NO) and prostaglandin E2 (PGE2) in LPS-activated macrophages. Among the five sub-fractions, the chloroform fraction (DP-C) showed the most potent suppressive effects against pro-inflammatory mediators and cytokines in LPS-stimulated macrophages. These effects were attributed to inhibition of nuclear factor-κB (NF-κB) nuclear translocation and c-Jun N terminal kinase (JNK) 1/2 phosphorylation and to activation of NF-E2-related factor 2/heme oxygenase-1 (Nrf2/HO-1) signaling. DP-C exhibited strong protective in vivo effects in TPA-induced ear edema mouse model and acetic acid-induced writhing response test. Our data suggest that DP-C has potent anti-inflammatory and analgesic activities and may be a promising treatment against a variety of inflammatory diseases.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 39 (5), 728-736, 2016
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204632369664
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- NII論文ID
- 130005149276
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 027270020
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- PubMed
- 27150144
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可