The Gastroprotective Effects of Eugenia dysenterica (Myrtaceae) Leaf Extract : The Possible Role of Condensed Tannins
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- Prado Ligia Carolina da Silva
- Laboratory of Pharmacology, Institute of Biomedical Sciences, Federal University of Uberlândia
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- Silva Denise Brentan
- Núcleo de Pesquisas em Produtos Naturais e Sintéticos, Faculty of Pharmaceutical Science at Ribeirão Preto, University of São Paulo
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- Oliveira-Silva Grasielle Lopes de
- Laboratory of Pharmacology, Institute of Biomedical Sciences, Federal University of Uberlândia
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- Hiraki Karen Renata Nakamura
- Laboratory of Histology, Institute of Biomedical Sciences, Federal University of Uberlândia
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- Canabrava Hudson Armando Nunes
- Laboratory of Pharmacology, Institute of Biomedical Sciences, Federal University of Uberlândia
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- Bispo-da-Silva Luiz Borges
- Laboratory of Pharmacology, Institute of Biomedical Sciences, Federal University of Uberlândia
書誌事項
- タイトル別名
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- The Gastroprotective Effects of <i>Eugenia dysenterica</i> (Myrtaceae) Leaf Extract: The Possible Role of Condensed Tannins
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説明
We applied a taxonomic approach to select the Eugenia dysenterica (Myrtaceae) leaf extract, known in Brazil as “cagaita,” and evaluated its gastroprotective effect. The ability of the extract or carbenoxolone to protect the gastric mucosa from ethanol/HCl-induced lesions was evaluated in mice. The contributions of nitric oxide (NO), endogenous sulfhydryl (SH) groups and alterations in HCl production to the extract’s gastroprotective effect were investigated. We also determined the antioxidant activity of the extract and the possible contribution of tannins to the cytoprotective effect. The extract and carbenoxolone protected the gastric mucosa from ethanol/HCl-induced ulcers, and the former also decreased HCl production. The blockage of SH groups but not the inhibition of NO synthesis abolished the gastroprotective action of the extract. Tannins are present in the extract, which was analyzed by matrix assisted laser desorption/ionization (MALDI); the tannins identified by fragmentation pattern (MS/MS) were condensed type-B, coupled up to eleven flavan-3-ol units and were predominantly procyanidin and prodelphinidin units. Partial removal of tannins from the extract abolished the cytoprotective actions of the extract. The extract exhibits free-radical-scavenging activity in vitro, and the extract/FeCl3 sequence stained gastric surface epithelial cells dark-gray. Therefore, E. dysenterica leaf extract has gastroprotective effects that appear to be linked to the inhibition of HCl production, the antioxidant activity and the endogenous SH-containing compounds. These pleiotropic actions appear to be dependent on the condensed tannins contained in the extract, which bind to mucins in the gastric mucosa forming a protective coating against damaging agents. Our study highlights the biopharmaceutical potential of E. dysenterica.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 37 (5), 722-730, 2014
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204632465152
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- NII論文ID
- 130004147318
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- NII書誌ID
- AA10885497
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- COI
- 1:STN:280:DC%2BC2cnpsVClsw%3D%3D
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 025419812
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- PubMed
- 24789995
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可