IL-1 and Allergy

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  • Nambu Aya
    Atopy Research Center, Juntendo University Frontier Research Initiative, The Institute of Medical Science, The University of Tokyo
  • Nakae Susumu
    Atopy Research Center, Juntendo University Frontier Research Initiative, The Institute of Medical Science, The University of Tokyo

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IL-1 is a well-characterized proinflammatory cytokine that is involved in host defense and autoimmune diseases. IL-1 can promote activation of T cells, including Th1 cells, Th2 cells and Th17 cells, and B cells, suggesting that IL-1 may contribute to the development of various types of T-cell-mediated diseases. This report reviews and discusses the role of IL-1 in the pathogenesis of allergic diseases based on studies using IL-1-related gene-deficient mice.<br>

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