Sulfatides Inhibit Adhesion, Migration, and Invasion of Murine Melanoma B16F10 Cell Line in Vitro
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- Ozawa Hiroki
- Faculty of Pharmacy, Keio University
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- Sonoda Yoshiko
- Faculty of Pharmacy, Keio University
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- Kato Saori
- Faculty of Pharmacy, Keio University
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- Suzuki Erika
- Faculty of Pharmacy, Keio University
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- Matsuoka Ryotaro
- Faculty of Pharmacy, Keio University
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- Kanaya Takayuki
- Faculty of Pharmacy, Keio University School of Pharmaceutical Sciences, International University of Health and Welfare
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- Kiuchi Fumiyuki
- Faculty of Pharmacy, Keio University
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- Hada Noriyasu
- Faculty of Pharmacy, Keio University
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- Kasahara Tadashi
- Faculty of Pharmacy, Keio University
書誌事項
- タイトル別名
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- Sulfatides Inhibit Adhesion, Migration, and Invasion of Murine Melanoma B16F10 Cell Line <i>in Vitro</i>
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抄録
Endogenous sulfatide, such as 3-sulfated galactosylceramide (3-sulfatide) has been reported to be involved in neuronal development and regulation of tumor cell metastasis. Recently, a new 6-sulfated glucosylceramide (6-sulfatide) has been isolated from the ascidian, Ciona intestinalis. To determine the antitumor function of the new sulfatide, we examined the effects of synthetic 6-sulfatide and 3-sulfatide on the metastatic features of a murine melanoma cell line, B16F10. Both sulfatides significantly inhibited the adhesion of melanoma cells onto fibronectin-coated tissue plates and, the motility and invasion of the cells, with 6-sulfatide showing stronger inhibitory activities. In addition, both sulfatides inhibited α5-, and β1- but not αv- or β3-integrin expression. Furthermore, these sulfatides inhibited the activation of focal adhesion kinase, Akt, and extracellular signal-regulated kinase signaling pathways, which are thought to be important for cell migration and invasion. Therefore, these sulfatides may serve as promising drug candidates for the treatment of cancer metastasis.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 35 (11), 2054-2058, 2012
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204632711552
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- NII論文ID
- 130001872262
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- NII書誌ID
- AA10885497
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- COI
- 1:STN:280:DC%2BC38bmsVaisQ%3D%3D
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 024033095
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- PubMed
- 22972421
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可