1β-Hydroxy-2-oxopomolic Acid Isolated from Agrimonia pilosa Extract Inhibits Adipogenesis in 3T3-L1 Cells

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  • Ahn Eun-Kyung
    Natural Products Research Institute, Gyeonggi Institute of Science & Technology Promotion
  • Lee Jung A
    Natural Products Research Institute, Gyeonggi Institute of Science & Technology Promotion
  • Seo Dong-Wan
    College of Pharmacy, Dankook University
  • Hong Seong Su
    Natural Products Research Institute, Gyeonggi Institute of Science & Technology Promotion
  • Oh Joa Sub
    Natural Products Research Institute, Gyeonggi Institute of Science & Technology Promotion College of Pharmacy, Dankook University

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  • 1β-Hydroxy-2-oxopomolic Acid Isolated from <i>Agrimonia pilosa</i> Extract Inhibits Adipogenesis in 3T3-L1 Cells

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In order to determine anti-adipogenic effect, this study investigated 1β-hydroxy-2-oxopomolic acid (HOA) isolated from Agrimonia pilosa inhibits adipocyte differentiation and expression of adipogenic marker genes, such as peroxisome proliferator activated receptor γ (PPARγ), CCAAT-enhancer-binding protein α (C/EBPα), glucose transporter 4 (GLUT4), adiponectin, adipocyte fatty acid-binding protein 2 (aP2), adipocyte determination and differentiation factor 1/sterol regulatory element binding protein 1c (ADD1/SREBP1c), resistin, and fatty acid synthase (Fas) in 3T3-L1 preadipocyte. We demonstrated that HOA induced a significant decrease in lipid accumulation and expression of adipogenic marker genes in a dose-dependent manner. In addition, HOA reduced the transcripitional activity of PPARγ induced by troglitazone, a potent diabetes agent; it also suppressed expression of PPARγ and C/EBPα protein levels. Our data suggest that HOA isolated from Agrimonia pilosa inhibits adipocyte differentiation through downregulation of various adipocytokines by blocking PPARγ and C/EBPα expression.

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