The Antioxidative Effect of a Novel Free Radical Scavenger 4'-Hydroxyl-2-substituted Phenylnitronyl Nitroxide in Acute High-Altitude Hypoxia Mice
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- Fan Peng-Cheng
- Department of Pharmacy, General Hospital of Lanzhou Command of PLA Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University
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- Ma Hui-Ping
- Department of Pharmacy, General Hospital of Lanzhou Command of PLA Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University
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- Jing Lin-lin
- Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University
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- Li Lin
- Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University Department of Pharmaceutics, School of Pharmacy, Lanzhou University
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- Jia Zheng-Ping
- Department of Pharmacy, General Hospital of Lanzhou Command of PLA Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University
書誌事項
- タイトル別名
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- The Antioxidative Effect of a Novel Free Radical Scavenger 4′-Hydroxyl-2-substituted Phenylnitronyl Nitroxide in Acute High-Altitude Hypoxia Mice
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抄録
Acute mountain sickness is caused by sub-acute hypoxia in healthy individuals going rapidly to altitude. Both tissue hypoxia in vitro and whole-body hypoxia in vivo have been found to promote the release of reactive oxygen species. Nitronyl nitroxide can trap free radicals such as ·NO or ·OH, and may therefore be efficient protective agents. This study assessed the ability of nitronyl nitroxide to against acute mountain sickness as a free radical scavenger in acute high-altitude hypoxia mice model. Normobaric hypoxia and hypobaric hypoxia model were used to estimate the protect effects of nitronyl nitroxide against acute mountain sickness. Low pressure oxygen compartment system was used to stimulate high-altitude hypobaric hypoxia environment. Mice in nitronyl nitroxide groups survived longer than acetazolamide group in normobaric hypoxia test. Hydrogen peroxide (H2O2) and malondialdehyde (MDA) increased in both cerebrum and myocardium in vehicle group. The results indicated more radicals were generated during high-altitude hypobaric hypoxia environment. In therapeutic groups H2O2 and MDA were significantly reduced while the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) were similar to normal group. These results demonstrated that nitronyl nitroxide was an efficient tissue radical scavenger and a potential protective agent for acute mountain sickness.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 36 (6), 917-924, 2013
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204633292800
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- NII論文ID
- 130003361455
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- NII書誌ID
- AA10885497
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- COI
- 1:STN:280:DC%2BC3svlsVOnuw%3D%3D
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 024524288
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- PubMed
- 23486089
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可