Inhibitory Effect of Gnetin C, a Resveratrol Dimer from Melinjo (Gnetum gnemon), on Tyrosinase Activity and Melanin Biosynthesis
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- Yanagihara Miyako
- Institute for Bee Products and Health Science, Yamada Apiculture Center, Inc.
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- Yoshimatsu Maiko
- Institute for Bee Products and Health Science, Yamada Apiculture Center, Inc.
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- Inoue Akinori
- Institute for Bee Products and Health Science, Yamada Apiculture Center, Inc.
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- Kanno Tomoko
- Research Center for Immunology & Analysis, Inc.
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- Tatefuji Tomoki
- Institute for Bee Products and Health Science, Yamada Apiculture Center, Inc.
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- Hashimoto Ken
- Institute for Bee Products and Health Science, Yamada Apiculture Center, Inc.
書誌事項
- タイトル別名
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- Inhibitory Effect of Gnetin C, a Resveratrol Dimer from Melinjo (<i>Gnetum gnemon</i>), on Tyrosinase Activity and Melanin Biosynthesis
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説明
Tyrosinase is the key enzyme involved in melanogenesis. The aim of this study was to investigate the in vitro inhibitory effects of gnetin C, a resveratrol dimer isolated from melinjo (Gnetum gnemon) seeds, on tyrosinase activity and melanin biosynthesis in murine B16 cells. The inhibitory activities of gnetin C and resveratrol were shown to be almost equal against tyrosinase and melanin biosynthesis in the cells. The IC50 values of gnetin C activity against tyrosinase and melanin biosynthesis were 7.0 and 7.6 µM, respectively, whereas resveratrol demonstrated IC50 values of 7.2 and 7.3 µM, respectively. These results indicated that gnetin C inhibited melanogenesis, in a manner similar to that of resveratrol, by inhibiting tyrosinase and may therefore function as a new skin-whitening agent. However, the direct effects of gnetin C and resveratrol on murine tyrosinase activities were not equal. The IC50 value of resveratrol was 10.1 µM, while gnetin C only exhibited a 25.2% enzyme inhibition at 16 µM. The IC25 values for gnetin C and resveratrol were 15.5 and 4.0 µM, respectively. Therefore, it is suggested that the effects of gnetin C may be due to mechanisms other than the direct inhibition of tyrosinase activity.
収録刊行物
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- Ｂｉｏｌｏｇｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ
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Ｂｉｏｌｏｇｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ 35 (6), 993-996, 2012
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204633395840
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- NII論文ID
- 130001872188
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- NII書誌ID
- AA10885497
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- COI
- 1:STN:280:DC%2BC38jgslCqsg%3D%3D
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 023665813
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- PubMed
- 22687546
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- JaLC
- NDLサーチ
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可