Inhibitory Activity to Neutrophil Adhesion and Antimicrobial Activity of Diluted Hydrosol Prepared from Rosa damascena

DOI DOI Web Site Web Site Web Site ほか2件をすべて表示 一部だけ表示 被引用文献2件 参考文献22件 オープンアクセス
  • Maruyama Naho
    Teikyo University Institute of Medical Mycology Department of Health and Dietetics, Faculty of Health and Medical Science, Teikyo Heisei University
  • Tansho-Nagakawa Shigeru
    Department of Microbiology and Immunology, Teikyo University School of Medicine
  • Miyazaki Chizuru
    Department of Microbiology and Immunology, Teikyo University School of Medicine
  • Shimomura Kazuyuki
    Department of Sport and Medical Science, Faculty of Medical Technology, Teikyo University
  • Ono Yasuo
    Department of Microbiology and Immunology, Teikyo University School of Medicine
  • Abe Shigeru
    Teikyo University Institute of Medical Mycology Department of Sport and Medical Science, Faculty of Medical Technology, Teikyo University

書誌事項

タイトル別名
  • Errata for Biological and Pharmaceutical Bulletin
  • Inhibition of Neutrophil Adhesion and Antimicrobial Activity by Diluted Hydrosol Prepared from <i>Rosa damascena</i>

この論文をさがす

説明

<p>Hydrosol prepared from the flowers of Rosa damascena (rose water) has been traditionally used for various health-related issues, including skin troubles such as erythema, itchiness, swelling. For the care of these skin troubles caused by microbial infection, both antimicrobial and antiinflammatory effects are required. Here, we investigated the effects of rose water on the growth of Candida albicans and methicillin-resistant Staphylococcus aureus (MRSA), which cause skin infections, and on the function of neutrophils, which play a major role in the regulation of inflammatory reactions. To assess its modulatory effects on neutrophils, the effects of rose water against neutrophil adhesion response were evaluated. Rose water inhibited mycelial growth of C. albicans at a concentration of ca. 2.2%, and reduced viability of MRSA within 1 h. Rose water suppressed neutrophil activation induced by lipopolysaccharide (LPS), tumor necrosis factor alpha (TNF-α), and N-formyl-Met-Leu-Phe (fMLP) at 5–15%. It also reduced the LPS- and TNF-α-induced cell surface expression of the adhesion-related molecule, cluster of differentiation (CD) 11b, but did not affect the migratory capacity of neutrophils with or without chemoattractant. These results suggest that rose water may reduce the pathogenicity of microbes, and attenuate neutrophil stimulation, which is involved in inflammatory responses. These findings suggest that rose water has a potential effect to inhibit skin inflammation caused by microbes.</p>

収録刊行物

被引用文献 (2)*注記

もっと見る

参考文献 (22)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ