Water Extracts of Immature Rubus coreanus Regulate Lipid Metabolism in Liver Cells

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  • Bhandary Bidur
    Department of Pharmacology, Institute of Cardiovascular Research, School of Medicine, Chonbuk National University
  • Lee Geum-Hwa
    Department of Dental Pharmacology, Wonkwang Dental Research Institute, Dental School, Wonkwang University
  • Marahatta Anu
    Department of Pharmacology, Institute of Cardiovascular Research, School of Medicine, Chonbuk National University
  • Lee Hak-Yong
    Department of Pharmacology, Institute of Cardiovascular Research, School of Medicine, Chonbuk National University
  • Kim Sun-Young
    Clinical Trial Center for Functional Foods, Chonbuk National University Hospital
  • So Byung-Ok
    Clinical Trial Center for Functional Foods, Chonbuk National University Hospital
  • Kwon Ji-Wung
    Gochang Black Raspberry Research Institute
  • Song Ji-Young
    Gochang Black Raspberry Research Institute
  • Lee Hee-Kwon
    Gochang Black Raspberry Research Institute
  • Kim Hyung-Ryong
    Department of Dental Pharmacology, Wonkwang Dental Research Institute, Dental School, Wonkwang University
  • Chae Soo-Wan
    Department of Pharmacology, Institute of Cardiovascular Research, School of Medicine, Chonbuk National University Clinical Trial Center for Functional Foods, Chonbuk National University Hospital
  • Chae Han-Jung
    Department of Pharmacology, Institute of Cardiovascular Research, School of Medicine, Chonbuk National University

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  • Water Extracts of Immature <i>Rubus coreanus</i> Regulate Lipid Metabolism in Liver Cells

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Hyperlipidemia is a major contributor for atherosclerosis and hypolipidemic drugs such as statin are highly prescribed to treat elevated lipid level in plasma. Rubus coreanus, which is widely cultivated in south eastern Asia, have been reported to show significant cholesterol lowering action in hyperlipidemic subjects. Our objective was to determine the cellular effect of Rubus coreanus extract (RCE) on cholesterol biosynthesis in human hepatic cells (HepG2) and to elucidate the molecular mechanism by which it causes change in cholesterol metabolism. RCE treatment lowered cholesterol biosynthesis as well as secretion from HepG2 cells. This effect was associated with lowering the release of apolipoproteins from hepatic cells. RCE treatment also showed an increase in phosphorylation of foxhead box protein 01 (FoXo-1) and 5-adenosine monophosphate-activated protein kinase (AMPK), thus lowering expression of phosphoenolpyruvate carboxykinase (PEPCK) and G6Pase, which might be a major pathway for cholesterol biosynthesis inhibition. Apart from this; RCE also lowered sterol regulatory element-binding protein-1 (SREBP-1) expression in HepG2 cells, showing a long term regulation of cholesterol biosynthesis activity. These results indicate that one of the anti-hyperlipidemic actions of RCE is due to inhibition of cholesterol biosynthesis in hepatic cells and provides first documentation of a hypolipidemic bio-molecular action of Rubus coreanus.

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