Effects of Sulfaphenazole after Collagenase-Induced Experimental Intracerebral Hemorrhage in Rats
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- Hama Sayuri
- Laboratory for Brain Science, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University
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- Ishihara Yasuhiro
- Laboratory of Molecular Brain Science, Graduate School of Integrated Arts and Sciences, Hiroshima University
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- Watanabe Masatomo
- Laboratory of Molecular and Cellular Neurosciences, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University
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- Danjo Sonoko
- Laboratory for Brain Science, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University Department of Neuropsychiatry, School of Medicine, Kagawa University
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- Nakamura Yu
- Department of Neuropsychiatry, School of Medicine, Kagawa University
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- Itoh Kouichi
- Laboratory for Brain Science, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University Laboratory of Molecular and Cellular Neurosciences, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University
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Treatment of intracerebral hemorrhage is often pointless, although considerable effort has been devoted to developing treatments for ischemic stroke. The purpose of this study was to determine the influence of drugs in improving neurological outcomes with pharmaceutical therapy after intracerebral hemorrhage. The free-radical hypothesis for intracerebral hemorrhage is based on the cytotoxicity triggered by blood components and its degradation products, such as heme and iron as a potent pro-oxidant atom. Sulfaphenazole (SPZ) has a different mechanism such as reactive oxygen species scavenging, in addition to the inhibition of superoxide production by cytochrome P450. The present study investigated the properties of SPZ in collagenase-induced intracerebral hemorrhage rat brain damage. The results show that systemic SPZ treatment after intracerebral hemorrhage reduces striatal dysfunction, the elevation of lipid peroxidation, and brain edema in the rat. These results suggest that SPZ is a potentially effective therapeutic approach for intracerebral hemorrhage as the effect of SPZ was initiated for either 1 h or 3 d post-intracerebral hemorrhage.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 35 (10), 1849-1853, 2012
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204633523840
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- NII論文ID
- 130001872384
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- NII書誌ID
- AA10885497
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- COI
- 1:STN:280:DC%2BC3s%2FisF2mtw%3D%3D
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 023973513
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- PubMed
- 23037177
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
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