Positive Effects of Hydrogen Water on 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis in NC/Nga Mice
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- Yoon Yang-Suk
- Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University
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- Sajo Ma. Easter Joy Villarosa
- Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University
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- Ignacio Rosa Mistica Coles
- Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University
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- Kim Soo-Ki
- Department of Microbiology, Wonju College of Medicine, Yonsei University
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- Kim Cheol-Su
- Department of Microbiology, Wonju College of Medicine, Yonsei University
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- Lee Kyu-Jae
- Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University Institute for Poverty Alleviation and International Development, Yonsei University
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抄録
Atopic dermatitis (AD) is a chronically relapsing, pruritic, eczematous skin disorder accompanying allergic inflammation. AD is triggered by oxidative stress and immune imbalance. In the present study, we investigated the effect of drinking hydrogen water (HW) on 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis in NC/Nga mice and found that HW ameliorated DNCB-induced AD-like clinical symptoms. In line with this, the level of reactive oxygen species in the HW group was significantly inhibited compared with that in the purified water (PW) group. In parallel, HW enhanced glutathione peroxidase activity in DNCB-induced AD as compared with the PW group. Accordingly, the levels of thymus and activation-regulated chemokine and cytokines were significantly decreased in the HW group compared with the PW group. Notably, the levels of Th2 cytokine, interleukin-5 (IL-5), and proinflammatory cytokines such as tumor necrosis factor-α and IL-6 in HW-fed mice were significantly lower than in control and PW-fed mice. The total serum immunoglobulin E level was also markedly reduced in the HW group. The collective results indicate that HW suppresses DNCB-induced AD in NC/Nga mice via redox balance and immune modulation and could be a safe clinical fluid treatment for AD.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 37 (9), 1480-1485, 2014
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204633739136
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- NII論文ID
- 130004684787
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- NII書誌ID
- AA10885497
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- COI
- 1:STN:280:DC%2BC2M%2FmvFKhtQ%3D%3D
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 025736897
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- PubMed
- 25177031
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可