Expression of Hepatic Fat-Specific Protein 27 Depends on the Specific Etiology of Fatty Liver
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- Aibara Daisuke
- Faculty of Pharmaceutical Science, Fukuoka University
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- Matsusue Kimihiko
- Faculty of Pharmaceutical Science, Fukuoka University
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- Matsuo Kohei
- Faculty of Pharmaceutical Science, Fukuoka University
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- Takiguchi Soichi
- Institute for Clinical Research, National Kyushu Cancer Center
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- Gonzalez Frank J.
- Laboratory of Metabolism, National Cancer Institute, National Institutes of Health
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- Yamano Shigeru
- Faculty of Pharmaceutical Science, Fukuoka University
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抄録
Fat-specific protein 27 gene (FSP27), isolated by screening for genes specifically expressed in fully differentiated mouse adipocytes, belongs to the cell death-inducing DNA fragmentation factor, alpha subunit-like effector family. FSP27 is induced in not only adipose tissue but also the liver of ob/ob mice, and it promotes the development of fatty liver. The FSP27 gene is expressed in a fatty liver-specific manner and is not detected in the normal mouse liver. FSP27 expression is directly regulated by the induction of the hepatic peroxisome proliferator-activated receptor γ (PPARγ) in ob/ob fatty liver. In the present study, expression of hepatic FSP27 mRNA was determined in non-genetic fatty liver models. The FSP27 gene was markedly induced in the high-fat- or methionine- and choline-deficient (MCD) diet-induced fatty liver, but it was not elevated in alcohol-induced fatty liver. Interestingly, the induction of FSP27 mRNA due to the MCD diet was independent of PPARγ levels and completely absent in the liver from PPARγ-null mice. These results suggest that FSP27 mRNA expression in the liver depends on the etiology of fatty liver.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 36 (11), 1766-1772, 2013
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204634302208
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- NII論文ID
- 130003382036
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- NII書誌ID
- AA10885497
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- COI
- 1:STN:280:DC%2BC2c7ivFynuw%3D%3D
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 024957711
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- PubMed
- 24189421
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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