Effects of Menthol on the Pharmacokinetics of Triazolam and Phenytoin
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- Hoshino Motohiro
- Department of Clinical Pharmacokinetics, Hoshi University
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- Ikarashi Nobutomo
- Department of Clinical Pharmacokinetics, Hoshi University
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- Hirobe Ryuta
- Department of Clinical Pharmacokinetics, Hoshi University
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- Hayashi Mami
- Department of Clinical Pharmacokinetics, Hoshi University
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- Hiraoka Hironori
- Department of Clinical Pharmacokinetics, Hoshi University
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- Yokobori Kohsuke
- Department of Clinical Pharmacokinetics, Hoshi University
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- Ochiai Takumi
- Department of Clinical Pharmacokinetics, Hoshi University
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- Kusunoki Yoshiki
- Department of Clinical Pharmacokinetics, Hoshi University
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- Kon Risako
- Department of Clinical Pharmacokinetics, Hoshi University
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- Tajima Masataka
- Department of Clinical Pharmacokinetics, Hoshi University
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- Ochiai Wataru
- Department of Clinical Pharmacokinetics, Hoshi University
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- Sugiyama Kiyoshi
- Department of Clinical Pharmacokinetics, Hoshi University
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説明
We have previously shown that menthol attenuates the anticoagulant effect of warfarin by increasing the expression levels of CYP3A and CYP2C in the liver. This study evaluated the effects of menthol on the pharmacokinetics of the CYP3A substrate triazolam and the CYP2C substrate phenytoin. Menthol was orally administered to mice for 7 d. Twenty-four hours after the administration of menthol, triazolam was orally administered, and the plasma concentration was measured. In addition, the CYP3A metabolic activity for triazolam and the CYP3A expression level in the liver were determined. The effects of menthol on the pharmacokinetics of phenytoin were assessed in the same manner. In the menthol-treated group, the area under the blood concentration–time curve (AUC) of triazolam was lower and its clearance was higher compared with the control group. The CYP3A metabolic activity and CYP3A expression level in the liver were significantly increased in the menthol-treated group compared with the control group. Similarly, the AUC of phenytoin was lower and the hepatic CYP2C expression level was higher in the menthol-treated group. Thus, menthol lowered the plasma concentrations of triazolam and phenytoin when concurrently administered. These effects may be attributed to an increased metabolic activity for these drugs due to the increased expression of CYP3A and CYP2C in the liver.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 38 (3), 454-460, 2015
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204634511488
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- NII論文ID
- 130004872268
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 026193319
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- PubMed
- 25757928
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可