Protective Effects of Genipin on Gastrointestinal Disorders
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- Sohn Yoon Ah
- College of Pharmacy, Duksung Women’s University
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- Hwang In Young
- College of Pharmacy, Duksung Women’s University
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- Lee Sun Yi
- College of Pharmacy, Duksung Women’s University
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- Cho Hyo Sun
- College of Pharmacy, Duksung Women’s University
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- Jeong Choon Sik
- College of Pharmacy, Duksung Women’s University
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<p>Genipin, an aglycone of geniposide, is a major component of gardeniae fructus, and has been used to treat jaundice, various inflammatory disorders, and liver disease, and has also been used as a natural cross-linking agent. The authors conducted several experiments to evaluate the protective effects of genipin on gastrointestinal disorders, such as, gastritis and gastric ulcers. Genipin showed inhibitory effects against HCl·ethanol-induced acute gastritis and indomethacin-induced gastric ulcers in rats and increased prostaglandin E2 (PGE2) in AGS gastric cancer cell. Genipin had significant effects on aggressive factors, acid-neutralization, and gastric secretion, and inhibited H+/K+-ATPase (a proton pump), which secretes gastric acid. The results obtained indicate that genipin has significant gastroprotective effects and might be useful for treating and preventing gastric lesions.</p>
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 40 (2), 151-154, 2017
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204634548352
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- NII論文ID
- 130005308426
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 027871534
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- PubMed
- 28154253
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可