血性髄液の無気環境下における変化クモ膜下出血後の病態特に血管攣縮との関連
書誌事項
- タイトル別名
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- The significance of anaerobic condition in the pathogenesis of cerebral vasospasm associated with subarachnoid hemorrhage
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説明
In the in vitro study of subarachnoid hemorrhage, the anaerobical incubation of CSF-blood mixture resulted in marked fall of its PH value. The fact suggested that intracranial focal acidosis may play some role in the pathogenesis of cerebral vasospasm or of disturbance of consciousness. To test this hypothesis, we treated 16 cases of such disorders with carotid injection of 7% sodium bicarbonate solution. The treatment resulted in considerable improvement of the disturbance of consciousness by dilating the cerebral peripheral arteries; this we could observe angiographically 15 minutes after the carotid injection. We found, however, no morphological changes in the spastic vessel itself up to 30 minutes after the injection.<BR>From the results of both this study and our previous experperiments, we offered the hypothesis that the synthesizing process of thromboxane A2 and intracranial focal acidosis might play an important role in the pathogenesis of cerebral vasospasm.
収録刊行物
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- 脳卒中
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脳卒中 3 (1), 1-8, 1981
一般社団法人 日本脳卒中学会
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詳細情報 詳細情報について
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- CRID
- 1390001204637182208
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- NII論文ID
- 130003631687
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- ISSN
- 18831923
- 09120726
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
