慢性期脳梗塞患者のヘマトクリット (Ht) 血液粘度の日内変動について

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  • A study of diurnal changes of hematocrit (Ht) and blood viscosity in patients with old cerebral infarction

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The attacks of cerebral infarction occur frequently during sleep or in the morning and diurnal changes of blood pressure and hematocrit (Ht) have been thought to be related to the attack.<BR>We studied the diurnal changes of hematocrit, blood and plasma viscosity, and blood pressure in 45 patients with old cerebral infarction and age matched 15 controls. Study was performed at 10 : 00 AM, 16 : 00, 22 : 00, and next 4 : 00 AM. The results were as followed.<BR>1) Ht and blood viscosity showed diurnal changes : minimal at 22 : 00, and maximal at 10 : 00 AM in the both groups, plasma viscosity changed slightly and showed maximum at 10 : 00 AM.<BR>2) Ht changing ratio (ΔHt) and blood viscosity changing ratio (Δ V) were calculated by the data at 10 : 00 AM to the data at 22 : 00 as below.<BR>ΔHt=10°-22°Ht/22°Ht×100%, ΔV=10°Viscosity-22°Viscosity/22°Viscosity×100%<BR>ΔHt and ΔV were higher in the cerebral infarction group than in the control group.<BR>3) ΔHt was higher in the penetrating artery infarction group (n=19) than in the cortical artery infarction group (n=18).<BR>4) Patients with higher ΔHt and high ΔV were characterized by double or more stroke atacks episode and multiple low densities in the brain CT.<BR>5) Diurnal changes of blood pressure was noticed neither in the patients nor in the controls.<BR>High Ht value and high blood viscosity have been known as risk factors of cerebral infarction, and diurnal changes of Ht and blood viscosity showing maximum in the morning were also considered to be one of the risk factors of cerebral infarctions.

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  • 脳卒中

    脳卒中 8 (3), 224-230, 1986

    一般社団法人 日本脳卒中学会

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