Relationship between atrial natriuretic peptide and endothelin-1 in patients with acute stroke.

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  • Ｎａ利尿ｐｅｐｔｉｄｅとＥｎｄｏｔｈｅｌｉｎ‐１動態の関係について　脳血栓症患者における検討
  • 脳血栓症患者における検討

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Abstract

The identification of atrial natriuretic peptide (ANP) in the cardiac atrium has disclosed a new functional role for the heart as an endocrine organ regulating body fluid homeostasis and blood pressure control. Recently, endothelin-1 (ET-1) has been shown to be a potent vasoconstrictor peptide which plays an important role in the pathogenesis of cerebrovascular disease. However, no simultaneous measurements of ANP and ET-1 have ever been attempted during the acute stage of cerebral thrombosis. The present study focuses on an evaluation of the changes in both ANP and ET-1 in the plasma over a period of 2 weeks following an episode of cerebral thrombosis. The AVP levels were also measured in the plasma samples. The plasma ANP concentration in the patients during the acute stage was elevated to 70.5 ± 80.9 pg/ml on day 1 (acute stage), followed by a significant decrease to 56.1 ± 7.0 pg/ml on day 14 (subacute stage). In addition, the level of ET-1 was 5.19 ± 1.91 pg/ml during the acute stage, and that during the subacute stage had declined to 2.79 ± 1.65 pg/ml. The ET-1 level at the acute stage was significantlt higher, when compared with that at the subacute stage. During the acute stage, the following relationship between the level of ET-1 (Y) and ANP (X) was obtained : Y = 0.019X + 3.864. The correlation between them was significant (r = 0.789, P <0.01). During the subacute stage also, the increased level of ET-1 (Y) showed an excellent linear relation ship with age (X) : Y = 0.015X + 1.979 X (r = 0.667, P < 0.01). The time course of induction of ET production is evidently consistent with elevated concentrations of ANP, and the data suggest that ANP release may be positively modulated by ET-1. The results of the present study support the hypothesis that ET-1 may be a potent secretagogue for ANP in the pathogenesis of cerebral thrombosis in vivo.

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