Adenocarcinoma of pancreas with non-suppurative fever, producing granulocyte-colony stimulating factor: a case report and literature review

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  • 非感染性発熱を伴いＧ－ＣＳＦ産生腫瘍であった膵癌の１症例

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A 58-year-old woman was referred to another hospital due to the presence of severe fever and general malaise. Laboratory data showed marked leucocytosis. Computed tomography showed pancreatic head cancer involving major vessels. At first the patient was suspected to have acute pancreatitis accompanied with pancreatic cancer. However, leucocytosis persisted irrespective of administration of antibiotic agents. The serum G-CSF concentration was elevated to 194pg/ml . Immunohistochemical examination of endoscopic ultrasound-fine needle aspiration revealed tumor cells were stained by anti G-CSF antibody. Chemotherapy by oral S-1 with gemcitabine was administered, together with steroidal therapy. The patient once appeared to respond to the therapy, and could be discharged from the hospital. However, 3 cycles after chemotherapy, her general condition worsened, and died 66 days after the first therapy. We suggest that the serum G-CSF should be examined in the case of cancer with non-suppurative leucocytosis.<br>

Journal

  • Suizo

    Suizo 25 (5), 585-590, 2010

    Japan Pancreas Society

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