Adrenomedullin動態と脳血管障害

書誌事項

タイトル別名
  • Plasma levels of adrenomedullin in patients with cerebrovascular disease.

この論文をさがす

抄録

Adrenomedullin (AM) is a potent hypotensive peptide newly discovered in pheochromocytoma tissue by monitoring its elevating effect on platelet cAMP. However, the possibility of AM acting as a new circulating hormone which participate in the pathogenesis of cerebrovascular disease (CVD) has never been investigated. We measured the plasma concentration of AM in patients with CVD by our recently established highly sensitive and specific RIA. The study population consisted of 22 patients with occlusive CVD and 8 patients with hemorrhagic CVD. The plasma AM during the acute stage was increased in the patients with occlusive CVD (37.0 ± 56.9 fmol/ml) as compared to those with hemorrhagic CVD (10.7 ± 6.2 fmol/ml). The increase in plasma AM during the acute stage was more prominent in patients with a Japan Coma Scale (JCS) of 100-300 than in patients with a JCS of 0-30. The time course of the AM levels in both occlusive CVD and hemorrhagic CVD indicated that that the values during the subacute stage were higher than those during both the acute stage and chronic stage. In conclusion, based on its potent vasodilator effect. AM may be involved in the pathogenesis of CVD.

収録刊行物

  • 脳卒中

    脳卒中 18 (4), 318-325, 1996

    一般社団法人 日本脳卒中学会

被引用文献 (1)*注記

もっと見る

参考文献 (25)*注記

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ