書誌事項
- タイトル別名
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- Expression of endothelin-1 in both endothelium and astrocytes of human stroke brain.
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The present study focuses on the localization of ET-like immunoreactivity in the human stroke brain and on the expression of ET-1 in both the endothelium and astrocytes in relation to the healing process of occlusive cerebrovascular disease (CVD). Five patients with occlusive CVD were examined. Immunohistochemical studies on the human stroke brain were performed using rabbit polyclonal anti-human ET-1 antibody (Peptide Institude Inc., Japan). In each stroke brain, the immunohistochemical method demonstrated heterogeneous staining for ET-1, with different intensities of immunoreactivity among the central MCA, boundary MCA and non-MCA tetritories. Within the boundary MCA tetritory, the endothelial cells of the brain capillaries exhibited strong staining for ET-1 like immunoreactivity. Foot processes from astrocytes demonstrated ET-1 immunoreactivity, were attached and contributed to the formation of the preendothelial cell basement membrane. It was found that the foot processes of astrocytes encircled the endothelial cells with strong staining for ET-1 and also expressed ET-1 immunoreactivity. ET-1 can thus be produced by astrocytes and endothelium, with interection between them. Our data provide strong evidence ot suggest that the expressions of ET-1 in astrocytes and endothelium are closely related to the healing process of occlusive CVD.
収録刊行物
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- 脳卒中
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脳卒中 17 (4), 332-340, 1995
一般社団法人 日本脳卒中学会
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詳細情報 詳細情報について
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- CRID
- 1390001204639824768
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- NII論文ID
- 130003631177
- 10005234728
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- NII書誌ID
- AN0020186X
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- ISSN
- 18831923
- 09120726
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可