Expression of endothelin-1 in both endothelium and astrocytes of human stroke brain.

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  • ヒト脳梗塞の血管内皮およびＡｓｔｒｏｃｙｔｅにおけるＥｎｄｏｔｈｅｌｉｎ‐１発現について

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Abstract

The present study focuses on the localization of ET-like immunoreactivity in the human stroke brain and on the expression of ET-1 in both the endothelium and astrocytes in relation to the healing process of occlusive cerebrovascular disease (CVD). Five patients with occlusive CVD were examined. Immunohistochemical studies on the human stroke brain were performed using rabbit polyclonal anti-human ET-1 antibody (Peptide Institude Inc., Japan). In each stroke brain, the immunohistochemical method demonstrated heterogeneous staining for ET-1, with different intensities of immunoreactivity among the central MCA, boundary MCA and non-MCA tetritories. Within the boundary MCA tetritory, the endothelial cells of the brain capillaries exhibited strong staining for ET-1 like immunoreactivity. Foot processes from astrocytes demonstrated ET-1 immunoreactivity, were attached and contributed to the formation of the preendothelial cell basement membrane. It was found that the foot processes of astrocytes encircled the endothelial cells with strong staining for ET-1 and also expressed ET-1 immunoreactivity. ET-1 can thus be produced by astrocytes and endothelium, with interection between them. Our data provide strong evidence ot suggest that the expressions of ET-1 in astrocytes and endothelium are closely related to the healing process of occlusive CVD.

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