Accelerated blood clearance of PEGylated liposomes after repeated injection

DOI 1 Citations 42 References
  • Ishida Tatsuhiro
    Department of Pharmacokinetics and Biopharmaceutics, Graduate School of Pharmaceutical Sciences, The University of Tokushima
  • Kiwada Hiroshi
    Department of Pharmacokinetics and Biopharmaceutics, Graduate School of Pharmaceutical Sciences, The University of Tokushima

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Other Title
  • リポソームとＤＤＳ　　ポリエチレングリコール表面修飾リポソームの繰り返し投与時に発現するａｃｃｅｌｅｒａｔｅｄ　ｂｌｏｏｄ　ｃｌｅａｒａｎｃｅ（ＡＢＣ）現象
  • ポリエチレングリコール表面修飾リポソームの繰り返し投与時に発現するaccelerated blood clearance(ABC)現象

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Description

We and a Dutch group have recently reported the accelerated blood clearance (ABC) phenomenon upon repeated injection of PEGylated liposomes, that is the enhanced accumulation of PEGylated liposomes in liver and consequently rapidly cleared the liposomes from blood circulation. The phenomenon is a general characteristic of liposomes and the induction of the phenomenon depends on the physicochemical property and dose of liposomes and animal species. In addition, our study indicated that the IgM secreted in response to first dose is involved in the occurrence of the phenomenon. In this article, our and a Dutch group's recent results related to the ABC phenomenon were described.

Journal

  • Drug Delivery System

    Drug Delivery System 19 (6), 495-510, 2004

    THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM

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