Particle design using nano-assembly structure of transglycosylated materials
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- Tozuka Yuichi
- Laboratory of Formulation Design and Pharmaceutical Technology, Osaka University of Pharmaceutical Sciences
Bibliographic Information
- Other Title
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- 添加剤のナノ集合体形成を利用した機能性微粒子設計
- テンカザイ ノ ナノ シュウゴウタイ ケイセイ オ リヨウ シタ キノウセイ ビリュウシ セッケイ
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Abstract
The feasibility of trans-glycosylated materials, e.g., α-glucosyl hesperidin, α-glucosyl stevia, and α-glucosyl rutin, to improve the dissolution and bioavailability of poorly water-soluble drug was investigated. Spray-dried particles of drug/trans-glycosylated materials showed a significantly higher dissolution rate and greater absorption profile compared with the commercial drug powder. Molecularly dispersed particles of drug/trans-glycosylated materials may be prepared by spray-drying. We found that trans-glycosylated materials formed different types of aggregated-nanostructures in aqueous media. Trans-glycosylated materials self-associated into particular small micelles with a core-shell like architecture, in which the hydrophobic skeleton is segregated from the aqueous exterior to form a novel drug-loading core surrounded by a hydrophilic shell of sugar groups. The difference in the affinity among drug and associated-nanostructures may relate to the magnitude of solubility enhancement, indicating that the structural similarity of drug and trans-glycosylated materials helped the solubilizing effect.
Journal
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- Drug Delivery System
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Drug Delivery System 30 (2), 111-120, 2015
THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM
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Details 詳細情報について
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- CRID
- 1390001204640747136
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- NII Article ID
- 130005083737
- 40020406560
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- NII Book ID
- AN10084591
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- ISSN
- 18812732
- 09135006
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- NDL BIB ID
- 026271754
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed