Drug discovery of non-standard peptide with genetic code reprogramming

DOI Web Site 28 References
  • Yamaguchi Atsushi
    Department of Chemistry, Graduate School of Science, The University of Tokyo
  • Katoh Takayuki
    Department of Chemistry, Graduate School of Science, The University of Tokyo
  • Suga Hiroaki
    Department of Chemistry, Graduate School of Science, The University of Tokyo

Bibliographic Information

Other Title
  • プロテインエンジニアリングを利用した次世代バイオ創薬　　遺伝暗号のリプログラミングを用いた特殊ペプチド創薬
  • 遺伝暗号のリプログラミングを用いた特殊ペプチド創薬
  • イデン アンゴウ ノ リプログラミング オ モチイタ トクシュ ペプチドソウヤク

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Description

This review discusses recent development of a new platform technology that enables us to discover "natural product-like" non-standard peptides against various therapeutic targets. This platform technology is referred to as RaPID system (Random non-standard Peptides Integrated Discovery) system, composed of FIT (Flexible In-vitro Translation) system coupled with an mRNA display. By means of this system, a library of macrocyclic peptides consisting of over trillion unique sequences could be constructed and rapidly screened for desired bioactive properties. We shall also discuss the importance of merging the non-standard peptide therapeutics with DDS as a perspective.

Journal

  • Drug Delivery System

    Drug Delivery System 26 (6), 584-592, 2011

    THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM

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