Brain-targeted drug and gene delivery by intranasal administration

DOI Web Site 12 References
  • Kanazawa Takanori
    Lab. of Pharmaceutical Technology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
  • Takashima Yuuki
    Lab. of Pharmaceutical Technology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences

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Other Title
  • 高分子ミセルをキャリアとする経鼻投与による脳への薬物・核酸デリバリー
  • コウブンシ ミセル オ キャリア ト スル ケイ ビ トウヨ ニ ヨル ノウ エ ノ ヤクブツ ・ カクサン デリバリー

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Abstract

Intranasal administration is a promising effective and non-invasive drug delivery to the brain without passing through the blood-brain barrier (BBB). Cell penetrating peptide-modified block copolymer micelles (MPEG-PCL-Tat) have potential for improvement of mucosal permeability and nose-to-brain transport efficiency. Here we review the advantages of our MPEG-PCL-Tat micelles for intranasal drug and gene delivery.

Journal

  • Drug Delivery System

    Drug Delivery System 28 (4), 318-327, 2013

    THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM

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