Gene delivery into stem cells by modified adenovirus vectors

DOI Web Site 41 References
  • Kawabata Kenji
    Laboratory of Gene Transfer and Regulation, National Institute of Biomedical Innovation
  • Sakurai Fuminori
    Laboratory of Gene Transfer and Regulation, National Institute of Biomedical Innovation
  • Mizuguchi Hiroyuki
    Laboratory of Gene Transfer and Regulation, National Institute of Biomedical Innovation Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Osaka University

Bibliographic Information

Other Title
  • 遺伝子・核酸医薬品のデリバリー　　改良型アデノウイルスベクターを用いた各種幹細胞への遺伝子デリバリー
  • 改良型アデノウイルスベクターを用いた各種幹細胞への遺伝子デリバリー
  • カイリョウガタ アデノ ウイルス ベクター オ モチイタ カクシュ カンサイボウ エノ イデンシ デリバリー

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Abstract

The application of adenovirus (Ad) vectors, which are widely used in gene therapy, depends on CAR (coxsackievirus and adenovirus receptor) expression on the cells. To overcome this problem, the capsid proteins of Ad vectors have been genetically modified. Here, we introduce several types of capsid-modified Ad vectors. Furthermore, we describe the application of capsid-modified Ad vectors into some kinds of stem cells for regenerative medicine.

Journal

  • Drug Delivery System

    Drug Delivery System 22 (2), 148-154, 2007

    THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM

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