Nanoparticle-Mediated Drug Delivery System for Coronary Artery Disease

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  • Matoba Tetsuya
    Department of Cardiovascular Medicine, Kyushu University Hospital
  • Koga Jun-ichiro
    Department of Cardiovascular Research, Development, and Translational Medicine, Kyushu University Center for Cardiovascular Disruptive Innovation
  • Nakano Kaku
    Department of Cardiovascular Research, Development, and Translational Medicine, Kyushu University Center for Cardiovascular Disruptive Innovation
  • Egashira Kensuke
    Department of Cardiovascular Research, Development, and Translational Medicine, Kyushu University Center for Cardiovascular Disruptive Innovation

Bibliographic Information

Other Title
  • 冠動脈疾患に対するナノ粒子・ドラッグデリバリーシステムの開発
  • カンドウミャク シッカン ニ タイスル ナノ リュウシ ・ ドラッグデリバリー システム ノ カイハツ

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Description

Coronary artery disease including acute myocardial infarction is a significant concern in cardiovascular medicine, because of their high acute mortality and morbidity causing lethal heart failure. Atherosclerotic plaque destabilization and rupture are central pathogenesis of acute myocardial infarction, whereas myocardial ischemia-reperfusion injury is another adverse phenomenon in the heart undergoing early reperfusion therapy for acute myocardial infarction. There are un-met needs for these pathological conditions to be overcome by the use of nanoparticle-mediated drug delivery system (DDS). We provide overview of the mechanistic background for the use of DDS and the efficacy of nano-medicine in preclinical disease models.

Journal

  • Drug Delivery System

    Drug Delivery System 30 (4), 299-308, 2015

    THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM

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