Development of transcutaneous vaccine formulations utilizing the microneedle technology

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  • Ito Sayami
    Laboratory of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University 1-6 Yamadaoka, Suita, Osaka
  • Nakagawa Shinsaku
    Laboratory of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University 1-6 Yamadaoka, Suita, Osaka
  • Okada Naoki
    Laboratory of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University 1-6 Yamadaoka, Suita, Osaka

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  • マイクロニードル技術を活用した経皮ワクチン製剤の開発
  • マイクロニードル ギジュツ オ カツヨウ シタ ケイヒ ワクチン セイザイ ノ カイハツ

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Abstract

Conventional vaccination is performed mainly by injection, which has several inherent problems: pain, the need for trained personnel, associated needle-related diseases or injuries, and storage or transport issues. In some areas, vaccine coverage against infection is low due to failure in follow-up as well as a lack of trained medical personnel and facilities. Thus, the development of needle-free, easy-to-use, and low-invasive vaccination methods is an urgent task. With its advantages that overcome the inherent problems of vaccination by injection, transcutaneous immunization is now attracting attention as an alternative vaccination route. Herein, we provide an outline of recent trends in the development of transcutaneous vaccine formulations utilizing the microneedle technology.

Journal

  • Drug Delivery System

    Drug Delivery System 32 (1), 39-45, 2017

    THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM

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