Potential application of mesenchymal stem cell-derived exosomes as a novel therapeutic drug

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  • Katsuda Takeshi
    Division of Molecular and Cellular Medicine,National Cancer Center Research Institute
  • Ochiya Takahiro
    Division of Molecular and Cellular Medicine,National Cancer Center Research Institute

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Other Title
  • 新規治療薬開発への間葉系幹細胞由来エクソソームの応用可能性
  • シンキ チリョウヤク カイハツ エ ノ カンヨウケイ カンサイボウ ユライ エクソソーム ノ オウヨウ カノウセイ

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Description

Secreted membrane vesicles called exosomes play important roles in intercellular communications. Exosomes contain various molecules such as proteins, microRNAs and mRNAs, and mimic, at least in part, the roles that are played by their originating cells. Thus, it is expected that mesenchymal stem cells (MSC)-derived exosomes (MSC-exosomes) can serve as drugs for various types of diseases, because MSCs have attracted much attention as a novel therapeutic source for a wide range of diseases. In this article, we will summarize the latest reports on the therapeutic potential of MSC-exosomes for several types of diseases. We also discuss possible therapeutic strategies using MSC-exosomes, and hurdles to be overcome for realization of MSC-exosome based therapy.

Journal

  • Drug Delivery System

    Drug Delivery System 29 (2), 140-151, 2014

    THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM

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