Histopathological Changes in Joint Components during Contracture-A Study of the Long Term Knee Joint Immobility Model in the Rat-

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  • WATANABE Masanori
    Department of Rehabilitation, Kanazawa Municipal Hospital
  • HOSO Masahiro
    Division of Rehabilitation Science, Department of Health Science, Graduate School of Medical Science, Kanazawa University
  • TAKEMURA Keiju
    Department of Rehabilitation, Yamanaka-spa Medical Center
  • YOSHIKUBO Hiroaki
    Division of Rehabilitation Science, Department of Health Science, Graduate School of Medical Science, Kanazawa University
  • MATSUZAKI Taro
    Division of Rehabilitation Science, Department of Health Science, Graduate School of Medical Science, Kanazawa University
  • KOJIMA Satoshi
    Department of Rehabilitation, Uno Hospital

Bibliographic Information

Other Title
  • 関節拘縮における関節構成体の病理組織学的変化―ラット膝関節長期固定モデルを用いた検討―
  • カンセツ コウシュク ニ オケル カンセツ コウセイタイ ノ ビョウリ ソシキガクテキ ヘンカ ラット シツカンセツ チョウキ コテイ モデル オ モチイタ ケントウ
  • -A Study of the Long Term Knee Joint Immobility Model in the Rat-
  • ─ラット膝関節長期固定モデルを用いた検討─

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Abstract

To reveal the changes of joint formation due to contracture we studied the histopathological changes using an exterior fixation model of the rat knee joint. Twenty Wistar male rats of 9-weeks of age had their right hind legs fixed in plaster a posture of maximum knee joint flexion. Four rats each were grouped into 2, 4, 8, 16 and 32 weeks fixation and their knee joints were observed under an optical microscope with hematoxylin-eosin staining. In the group of 2 weeks fixation, we recognized atrophy and fiber outgrowth of fat tissues surrounding the joint and those changes developed along with prolongation of fixation. Adhesion of the arthrodial cartilage to adjacent tissues was obsereved in the group of 4 weeks fixation. From the groups after 16 weeks fixation, there were examples of the cnemis and femur connecting with tissues. After long term plaster fixation of 32 weeks, the whole joint formation had developed atrophy, fibrination and narrowing articular cavity leading to tissue ankylosis. Inflammation and cartilage necrosis or disappearance were not observed.<br>

Journal

  • Rigakuryoho Kagaku

    Rigakuryoho Kagaku 22 (1), 67-75, 2007

    The Society of Physical Therapy Science

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