The significance of disease-independence in Mikulicz's disease-Revival interests in Mikulicz's disease-

DOI Web Site PubMed 16 Citations 40 References
  • YAMAMOTO Motohisa
    First Department of Internal Medicine, Sapporo Medical University School of Medicine
  • SUZUKI Chisako
    First Department of Internal Medicine, Sapporo Medical University School of Medicine
  • NAISHIRO Yasuyoshi
    First Department of Internal Medicine, Sapporo Medical University School of Medicine
  • TAKAHASHI Hiroki
    First Department of Internal Medicine, Sapporo Medical University School of Medicine
  • SHINOMURA Yasuhisa
    First Department of Internal Medicine, Sapporo Medical University School of Medicine
  • IMAI Kohzoh
    Sapporo Medical University

Bibliographic Information

Other Title
  • ミクリッツ病における疾患独立性の意義‐Ｒｅｖｉｖａｌ　ｏｆ　ｉｎｔｅｒｅｓｔｓ　ｉｎ　Ｍｉｋｕｌｉｃｚ’ｓ　ｄｉｓｅａｓｅ‐
  • —Revival interests in Mikulicz's disease—
  • —Revival of interests in Mikulicz's disease—

Search this article

Abstract

  Mikulicz's disease represents a unique condition involving enlargement of the lacrimal and salivary glands. Mikulicz's disease has been considered part of primary Sjögren's syndrome because both diseases were histologically similar. However, the gland swellings in Mikulicz's disease are persistent, and its decreased secretional function is good responsiveness to glucocorticoid. Serologically, Mikulicz's disease is characterized by few autoantibody including anti-SS-A and anti-SS-B antibodies. Recently, it is revealed elevated IgG4 concentrations in the serum and prominent infiltration by plasmacytes expressing IgG4 in the lacrimal and salivary glands in Mikulicz's disease. Prominent IgG4-positive plasma cells are also detected in systemic lymph tissues. We cannot detect the phenomenon in Sjögren's syndrome. In complications with Mikulicz's disease, there are autoimmune pancreatitis, retroperitoneal fibrosis, tubulointerstitial nephritis, autoimmune hypophysitis, Riedel's thyroiditis, which are related to IgG4 in its pathogenesis. Mikulicz's disease is different from Sjögren's syndrome, and may be a systemic IgG4-related plasmacytic disease.<br>

Journal

Citations (16)*help

See more

References(40)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top