Heme oxygenase and its role in defense system ; Paradigm shift of anti-inflammatory therapy
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- YACHIE Akihiro
- Department of Clinical Laboratory Science, Division of Health Sciences, Kanazawa University Graduate School of Medical Science
Bibliographic Information
- Other Title
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- ヘムオキシゲナーゼと生体防御機構;抗炎症治療のパラダイムシフト
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Description
Heme oxygenase (HO) plays a central role in heme metabolism. At the same time, it protects cells from injury evoked by various oxidative stresses. A detailed analysis of the first human case of HO-1 deficiency revealed that HO-1 is involved in the protection of multiple tissues and organs. It is particularly important that in vivo HO-1 production is localized to selected cell types, e.g. renal tubular epithelium, reflecting the fact that HO-1 plays particularly important protective roles in these cells. In addition to renal epithelial cells and tissue macrophages, a minor subpopulation of circulating monocytes produced low, but significant levels of HO-1 and the number of these monocytes increased during episodes of acute inflammatory illnesses, indicating that monocytes play significant roles in controlling inflammation. On the other hand, excessive level of HO-1 induced by HO-1 gene transfection led to paradoxical susceptibility of the cells to oxidative injury. These results indicated that HO-1 expression is carefully controlled in vivo with regard to its location and the magnitude. Furthermore, it has been recently shown that HO-1 is involved in the immune regulation mediated by regulatory T cells. From these findings, it seems feasible to meticulously induce HO-1 protein in vivo as a novel therapeutic intervention to control various forms of inflammatory disorders.<br>
Journal
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- Japanese Journal of Clinical Immunology
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Japanese Journal of Clinical Immunology 30 (1), 11-21, 2007
The Japan Society for Clinical Immunology
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Details 詳細情報について
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- CRID
- 1390001204649816448
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- NII Article ID
- 10018857951
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- NII Book ID
- AN00357971
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- ISSN
- 13497413
- 09114300
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- HANDLE
- 2297/24733
- 2297/35869
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- PubMed
- 17332700
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- Text Lang
- ja
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- Article Type
- journal article
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- Data Source
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- JaLC
- IRDB
- Crossref
- CiNii Articles
- KAKEN
- OpenAIRE
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- Abstract License Flag
- Disallowed