Occurrence of recurrent stomatitis, watery diarrhea and erythema nodosum in a patient with 20 year history of Takayasu's disease.Coexistence of Takayasu's disease and incomplete BehCet's disease ?

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  • Nakano Satomi
    Department of Internal Medicine, Central Clinical Laboratories, Keio University, School of Medicine
  • Tsuzaka Kensei
    Department of Internal Medicine, Central Clinical Laboratories, Keio University, School of Medicine
  • Akizuki Masashi
    Department of Internal Medicine, Central Clinical Laboratories, Keio University, School of Medicine
  • Hibi Norifumi
    Department of Internal Medicine, Central Clinical Laboratories, Keio University, School of Medicine
  • Mukai Makio
    Division of Surgical Pathology, Central Clinical Laboratories, Keio University, School of Medicine

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Other Title
  • 高安病の経過中に口腔粘膜のアフタ性潰よう，結節性紅斑，多発性大腸びらんを発症し不全型ベーチェット病の併発が疑われた１例

Description

A 63-year-old woman with a 20-year-history of Takayasu's arteritis was admitted to Keio University Hospital because of fever, oral ulcer, watery diarrhea and erythema nodosum on her legs. Barium enema and endoscopic examination showed multiple erosions in the sigmoid colon. With a tentative diagnosis of incomplete Behçet's disease, administration of prednisolone with an initial daily dose of 30mg was started. The clinical symptoms and laboratory findings showed prompt responses to the steroid therapy. Three additional cases which described coexistence of Takayasu's disease and Behçet's disease have been reported. These patients were characterized by prominent intestinal symptoms and absence or mild ocular lesions. In two patients including present case, HLA typing was done and both had HLA-B 52 and DR 2. A possibility of existence of homogeneous group of patients with unique clinical presentations of Takayasu's disease and Behçet's disease was discussed.

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