反復性感染症がみられ全身性エリテマトーデスを併発した後天性ＩｇＡ欠損症の１例

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  • A case of acquired selective IgA deficiency with systemic lupus erythematosus: Consideration of relationship between recurrent infection and occurring of systemic autoimmune diseases in selective IgA deficiency.

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Selective IgA deficiency associated with systemic autoimmune diseases has been reported by many groups. However, there have been few reports concerning the observation that systemic autoimmune disease broke out in the course of IgA deficiency.<br> A 45-years-old woman with selective IgA deficiency induced by anticonvulsant medication has been followed for a few years. She developed polyarthritis with positive rheumatoid factor and was diagnosed as rheumatoid arthritis.<br> After 6 month, systemic lupus erythematosus with nephrotic syndrome has been developed. Lack of secretary IgA and decreased level of serum IgG 2 which might induce recurrent infection was observed. Although the origin of the association between selective IgA deficiency and occurrence of autoimmune diseases is hypothetical, we discussed the relations among selective IgA deficiency, recurrent infection, long term anticonvulsant medication and occurrence of SLE.

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