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Molecular diffusion analysis in the vertebral bone: phantom study

  • UEDA Yu
    Division of Health Sciences, Graduate School of Medical Science, Kanazawa University
  • MIYATI Tosiaki
    Division of Health Sciences, Graduate School of Medical Science, Kanazawa University
  • SAWA Kentaro
    School of Health Sciences, Faculty of Medicine, Kanazawa University
  • KASAI Harumasa
    Department of Radiology, Nagoya City University Hospital
  • KAWANO Makoto
    Department of Radiology, Nagoya City University Hospital
  • HARA Masaki
    Department of Radiology, Nagoya City University Hospital
  • SHIBAMOTO Yuta
    Department of Radiology, Nagoya City University Hospital
  • OHNO Naoki
    Division of Health Sciences, Graduate School of Medical Science, Kanazawa University

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Other Title
  • 椎体における水分子拡散の解析 : ファントムにおける検討

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Abstract

The purpose of our study is to evaluate restricted diffusion of the water molecules caused by the trabecular bone structure of the vertebra using a phantom. On a 1.5-T MRI, single shot diffusion echo planar imaging was used with b factors of 0, 500, and 1000s/mm2, effective TE of 80 ms, and TR of 2000ms. We determined ADC values with an original phantom, which consists of sponges with different space diameters and dry vertebral bone into the container filled with pure water We assessed the effects of values (0, 500, 1000s/mm2) and acquisition matrix (64×64, 128×128, 256×256) . ADC of the sponge increased as space diameter due to change in restricted diffusion of the water molecules, and was the same level of the dry vertebral bone. Moreover, ADC varied with b values and matrix sizes. Our original phantom enables to analyze restricted diffusion, and ADC is affected by the trabecular bone structure.

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