Pretreatment Methods for Selections Lung Cancer Markers in Mouse Urine

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  • HANAI Yosuke
    FIRST Research Center for Innovative Nanobiodevices
  • BABA Yoshinobu
    FIRST Research Center for Innovative Nanobiodevices Department of Applied Chemistry, Graduate School of Engineering Nagoya University

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Other Title
  • マウス尿中肺がんマーカー候補選定のための前処理法
  • アナリティカルレポート マウス尿中肺がんマーカー候補選定のための前処理法
  • アナリティカルレポート マウス ニョウチュウ ハイ ガン マーカー コウホ センテイ ノ タメ ノ マエショリホウ

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Abstract

Lung cancer is a leading cause of cancer-related deaths. Hence, developing early stage diagnostic tests that are highly sensitive and specific is crucial. In order to achieve a desirable preventive medicine in the future, a non-invasive diagnostic technique with a volatile biomarker is a key. In this work, we compared VOCs obtained from the urine of tumor-bearing mice and normal control mice, and found 21 VOCs to be candidate biomarkers for lung cancer. To more efficiently extract the candidate biomarkers, we tested five different pretreatment methods. Among these the most improved extraction efficiency was the addition of sodium chloride along with a heat treatment.

Journal

  • BUNSEKI KAGAKU

    BUNSEKI KAGAKU 62 (5), 437-442, 2013

    The Japan Society for Analytical Chemistry

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