TOXICITY AND DOSE-RESPONSE (EFFECT) RELATIONSHIP OF n-HEXANE

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Other Title
  • ｎ‐ヘキサンの毒性と量・反応関係
  • n ヘキサン ノ ドクセイ ト リョウ ハンノウ カンケイ

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Description

A large amount of n-hexane is being widely used in industry as a solvent or a component of the mixed solvents for extraction of vegitable oils, adhesives, paints, and for cleaning, etc. And, many cases of polyneuropathy due to n-hexane have been reported up to now. Recently, studies on the neurotoxicity and metabolism of n-hexane rapidly progressed in many countries. The present review covers clinical signs and symptoms, pathological changes, metabolism, dose-response (effect) in acute exposure, glue or thinner sniffers, workers, animal experiments. The joint effects and the maximal allowable concentration of n-hexane are also briefly discussed.

Journal

  • Sangyo Igaku

    Sangyo Igaku 22 (6), 470-487, 1980

    Japan Society for Occupational Health

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