真珠岩を特殊処理した油除去剤によるラット肺組織に対する線維増殖刺激性に関する実験的研究

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タイトル別名
  • AN EXPERIMENTAL STUDY ON FIBROGENESITY OF THE OIL ABSORBANT PARTICLES MADE OF PERLITE EXPANDED
  • シンジュガン オ トクシュ ショリシタ ユ ジョキョザイ ニヨル ラット ハイ

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説明

We examined the tissue reaction of the oil absorbant particles made of perlite “expanded.” Five milligrams of perlite dust suspended in 5% alcohol was infused intratraheally into lungs of rats, and 12 weeks after the injection tissues from the left lung of the rats were examined pathohistologically. Tissue hydroxyproline in the right lung of each rat was quantitatively determined.<BR>The results are summerized as follows.<BR>Twelve weeks after the injection, some of the alveolar ducts and alveoli were filled with particles of perlite duct, and the wall of these alveoli was thickened in which phagocytes and lymphocytes were observed. Giant cell granulomatous foci and infiltration of numerous mononuclear or rounded cells were found in the interstitium of the intraalveolar septa of the lung. In these foci fibroblast prolifilation was observed, but the replacement to collagen fibers was not so strong. Glallet's cell prolifilation was observed sporadically. The amount of tissue hydroxyproline was estimated to be 3.95±0.59 mg (per dry weight) for the perlite group, 5.62±0.94mg for the quartz sands group and 6.38 ±1.89mg for the kaolin group.<BR>The results suggest that the perticles of perlite “expanded” does not show so strong fibrogenesity to the lung tissue. However, the lung would have shown fibrosis slowly but steadily, if large quantity of particles of perlite had been depositted for a long time in the alveoli.

収録刊行物

  • 産業医学

    産業医学 20 (6), 367-373, 1978

    社団法人 日本産業衛生学会

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