Roles of testosterone on maturation of retention mechanism of extinction memory after conditioned taste aversion learning in mice.

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  • SUZUKI Ema
    Learning and Memory Project, Tokyo Metropolitan Institute of Medical Science Laboratory of Behavioral Neuroscience, Faculty of Science, Japan Women’s University
  • MIYAMOTO Takenori
    Laboratory of Behavioral Neuroscience, Faculty of Science, Japan Women’s University

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  • マウス味覚嫌悪学習後の消去記憶保持機構の成熟に対するテストステロンの役割
  • マウス ミカク ケンオ ガクシュウ ゴ ノ ショウキョ キオク ホジ キコウ ノ セイジュク ニ タイスル テストステロン ノ ヤクワリ

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Abstract

Food likes and dislikes can change with experience; conditioned taste aversion (CTA) is one of the examples. When animals consume a novel taste (conditioned stimulus, CS) followed by an experience of a poisoning symptom (unconditioned stimulus, US), they develop aversion to the CS (CTA learning), resulting in the acquisition of the CTA memory. If the animals experience the repeated presentations of the CS without the US after CTA learning, they can exhibit preference to the CS (extinction learning), resulting in the acquisition of the extinction memory. Recently, a number of studies have suggested that sex hormones play a crucial role in neural and hormonal control of behavior. In this review, we focus on some roles of androgens on brain mechanisms relevant for the extinction memory after CTA learning from the viewpoint of the sexual maturation in mice. Our behavioral experiments show that the retention process of the extinction memory after CTA learning is affected by one of androgens, testosterone, which promotes sexual maturation. The maturation of the retention mechanism of the extinction memory requires exposure of the amygdala and the ventral medial prefrontal cortex (vmPFC), which are related to the CTA and extinction memories, to testosterone in two steps (sexual pre- and post- maturation period). In male mice, the exposure during the sexual pre-maturation period is essential for testosterone-dependent maturation of the retention mechanism of the extinction memory during the sexual post-maturation period.

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