AMP kinase as an energy sensor in eukaryotic cells
-
- MANABE Yasuko
- Department of Health Promotion Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University
-
- GOTO-INOUE Naoko
- Department of Health Promotion Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University
-
- TAKAGI Mayumi
- Department of Health Promotion Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University
-
- FUJII Nobuharu L.
- Department of Health Promotion Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University
Bibliographic Information
- Other Title
-
- 真核細胞のエネルギー・センサー「AMPキナーゼ」
- シンカク サイボウ ノ エネルギー ・ センサー 「 AMP キナーゼ 」
Search this article
Abstract
The AMP-activated kinase (AMPK) is an evolutionarily conserved metabolic sensor, which maintaines cellular energy homeostasis. Homologs of AMPK are found in all eukaryotic animals, sucrose nonfermenting 1(SNF1) in yeast, snf1-related kinase 1 (SnRK1) in plants, AMP-activated kinase (AAK) in worms, and AMPK in flies. AMPK is a heterotrimer consisting of α-catalitic subunit, β and γ-regulatory subunits. AMPK is activated by starvation, the depletion of energy source and some stresses followed by enhancement of energy producing catabolic reactions and suppression of energy consuming anabolic reactions. Historically, activation of AMPK was believed to be regulated by allosteric binding of AMP and ATP at γ-regulatory subunits. However, recent reports suggest that AMPK is regulated by binding of not only AMP and ATP, but also ADP. <BR> In this review, we focused on the structure, function and regulation of AMPK in representative eukaryotic animals and also describes multiple metabolic regulations induced by AMPK activation.
Journal
-
- Hikaku seiri seikagaku(Comparative Physiology and Biochemistry)
-
Hikaku seiri seikagaku(Comparative Physiology and Biochemistry) 29 (2), 70-75, 2012
THE JAPANESE SOCIETY FOR COMPARATIVE PHYSIOLOGY AND BIOCHEMISTRY
- Tweet
Keywords
Details 詳細情報について
-
- CRID
- 1390001204668620672
-
- NII Article ID
- 10030727743
-
- NII Book ID
- AN10391932
-
- ISSN
- 18819346
- 09163786
-
- NDL BIB ID
- 023679011
-
- Text Lang
- ja
-
- Data Source
-
- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
-
- Abstract License Flag
- Disallowed