書誌事項
- タイトル別名
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- Disposition of Q-35. (1). Absorption and Excretion after Single Administration of 14C-Q-35 in Rats.
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説明
The absorption and excretion of 14C labeled Q-35[(±)-1-Cyclopropyl-6-fluoro-1, 4-dihydro-8-methoxy-7-(3-methylaminopiperidin-1-yl)-4-oxoquinoline-3-carboxylic acid], a new fluoroquinolone antimicrobial agent, were studied in rats.<BR>1. When 14C-Q-35 was administered orally at the dose of 20 mg/kg to fasted rats, the radioactivity was absorbed rapidly and reached a maximum plasma concentration (Cmax) at 0.38 h, thereafter was eliminated at a half-life of 2.84 h.<BR>The AUC of the plasma radioactivity after an oral administration of 14C-Q-35 to nonfasted rats decreased to about half of AUC in fasted rats. It was suggested that there was a significant decrease in the extent of absorption by food.<BR>2. It was suggested that 14C-Q-35 was absorbed from the upper and middle segments of small intestine but scarcely from the stomach as revealed by the loop method of the digestive tracts.<BR>3. The urinary and fecal excretion rate of the radioactivity during 72 h after an oral administration of 14C-Q-35 to fasted rats were 42.2% and 56.5 % (total: 98.6%) of dose, respectively. It was suggested that the administered radioactivity was excreted in about 100% into the urine and feces.<BR>4. The biliary excretion rate during 24h after an oral administration of 14C-Q-35 to nonfasted rats was 32.3% of the dose, and the quarter of the radioactivity excreted to bile was reabsorbed.
収録刊行物
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- 薬物動態
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薬物動態 10 (5), 595-603, 1995
日本薬物動態学会
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詳細情報 詳細情報について
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- CRID
- 1390001204669717760
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- NII論文ID
- 10007529849
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- NII書誌ID
- AN10144117
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- ISSN
- 09161139
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
