Prospective Multi-Center Trial for the Efficacy of Ecabet Sodium on the Relief of Dyspepsia in Korean Patients with Chronic Gastritis

DOI 被引用文献1件 参考文献15件
  • Kim Hak Yang
    Department of Gastroenterology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine
  • Hahm Ki-Baik
    Digestive Disease Center, Daejin Medical Center Jesaeng Hospital at Bundang
  • Choi Myung-Gyu
    Department of Medicine, The Catholic University of Korea Kangnam St. Mary’s Hospital
  • Rew Jong-Sun
    Department of Medicine, Chonnam National University Hospital
  • Seol Sang-Young
    Department of Medicine, Inje University Busan Paik Hospital
  • Chun Hoon-Jai
    Department of Medicine, Korea University Hospital
  • Lee Oh-Young
    Department of Medicine, Hanyang University Hospital
  • Hong Weon-Seon
    Division of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine

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Anti-peptic and anti-inflammatory actions of ecabet sodium might be beneficial in either improving gastritis or relieving dyspeptic symptoms. This study was designed to evaluate the clinical efficacy of ecabet sodium on dyspeptic symptoms and to elucidate the molecular mechanism attributable to symptom relief in patients with chronic gastritis. Two hundred and sixty eight chronic gastritis patients with persistent dyspepsia received ecabet sodium 1 g b.i.d. for 2 weeks, after which dyspeptic symptoms were reassessed with a questionnaires as before. The changes of interleukin-8 (IL-8), inducible nitric oxide synthase (iNOS), prostaglandin E2 (PGE2), and vascular endothelial growth factor (VEGF) levels in gastric juices were measured by ELISA. The changes of nitrotyrosine in gastric mucosa were measured by immunohistochemical staining. The most common dyspeptic symptom in Korean patients with chronic gastritis was epigastric soreness (76.8%), which was improved significantly after ecabet sodium treatment (81.7%, p<0.001). Ecabet sodium was more effective in patients with epigastric pain than vague abdominal discomfort (p = 0.02), especially in patients with old age. Complete relief of discomfort was more highly achieved in patients with positive Helicobacter pylori than without (p = 0.01). In spite of clear tendency that the decreased levels of IL-8, iNOS, and PGE2 and increased levels of VEGF were measured in gastric juices after ecabet sodium treatment, no statistical significance was noted, which might be due to high inter-individual variations. The nitrotyrosine expressions were significantly decreased after ecabet sodium treatment than before (p<0.01). In conclusion, ecabet sodium treatment was very useful for the relief f dyspeptic symptoms in chronic gastritis, to which both attenuated inflammatory and enhanced regenerative mechanisms were contributive.<br>

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